| South Drefia | Darashia | 1 | 1 |
| Southern crab constellation | Marapur | 1, Surface | 2 |
| Southern gate | Venore | 1 | 1 |
| Sparkling Pools (equip energy + fire protection) | Marapur | -8 | 2 |
| Spawn of golden key 0808 | Gray Beach | 2 | 1 |
| Special plum tree | Kazordoon | 1 | 1 |
| Special task: Tiquanda’s Revenge | Port Hope | Surface | 1 |
| Spectulus | Edron | 6 | 1 |
| Spheric teleporter to Darklight Core (boss: Vemiath) | Oramond | -8 | 1 |
| Spheric teleporter to Gloom Pillars (boss: Chagorz) | Oramond | -7 | 1 |
| Spheric teleporter to Jaded Roots (boss: Murcion) | Oramond | -7 | 1 |
| Spheric teleporter to Putrefactory (boss: Ichgahal) | Oramond | -7 | 1 |
| Spider lair | Rookgaard | Surface | 1 |
| Spirit Grounds (world change) | Dawnport | Surface | 1 |
| Spite of the Emperor | Yalahar | -7 | 1 |
| Splint | Marapur | 1 | 1 |
| Spore | Gnomegate | -4 | 17 |
| Spore reservoir | Issavi | -7, -8 | 12 |
| Srezz Yellow Eyes | Darashia | -5 | 1 |
| Stack tile for pre-boss Versperoth | Edron | -5 | 1 |
| Star Room | Darashia | -3 | 1 |
| Statue of Amati | Marapur | Surface | 1 |
| Statue of the snake god | Port Hope | -4 | 1 |
| Stealth task | Issavi | -2 | 1 |
| Steamboat | Marapur | -7 | 1 |
| Steamboat to Kazordoon | Kazordoon | -7 | 1 |
| Steamboat to Kazordoon and Farmine | Feyrist | Surface | 1 |
| Steamboat to Robson's Isle | Kazordoon | -3 | 1 |
| Stone golems room | Boss Lairs | -4 | 1 |
| Stone Tomb (boss: Thalas) <hidden> | Southern Darama | Surface | 1 |
| Stony pond | Roshamuul | Surface | 1 |
| Strange machine | Gray Beach | -1 | 1 |
| Strange shrine | Darashia | -3 | 5 |
| Strong water vortex | Gray Beach | -8 | 1 |
| Sugar | Feyrist | -1, -2 | 3 |
| Sugar Daddy | Feyrist | -2 | 1 |
| Sugar Mommy (exact spawn tile; only during weekends) | Feyrist | -2 | 1 |
| Suntower | Ab'Dendriel | Surface | 1 |
| Supplies task | Blue Valley | Surface | 1 |
| Svargrond | Gnomegate | -2 | 1 |
| Swamp trolls / rotworms | Venore | Surface | 1 |
| Swim | Krailos | Surface | 1 |
| Switch | Darashia | -6, -7 | 18 |
| Tamru the Black (exact spawn tile) | Tiquanda | Surface | 1 |
| Tanjis | Gray Beach | -4 | 2 |
| Tanjis (exact spawn tile) | Gray Beach | -4 | 1 |
| Tarbaz | Southern Darama | -5 | 1 |
| Tarpit Tomb (boss: Morguthis) <hidden> | Southern Darama | Surface | 1 |
| Task boss: Bretzecutioner | Svargrond | -3 | 1 |
| Task boss: Deathbine | Port Hope | Surface | 1 |