| Shadow bite berries | Venore | -2 | 2 |
| Shadow Tomb (boss: Mahrdis) <hidden> | Southern Darama | Surface | 1 |
| Shadowstalker (spawn location) | Gray Beach | -1 | 1 |
| Shark teeth | Krailos | Surface | 1 |
| Shattered Isles portals | Travora | Surface | 1 |
| Shield of destiny (TibiaRoyal) | Thais | -3 | 1 |
| Shield of endless search (OrcSearch) | Thais | -3 | 1 |
| Shimmering pearl | Marapur | -1 | 1 |
| Ship | Gray Beach | -8 | 1 |
| Ship to the Mainland | Isle of Destiny | Surface | 1 |
| Shlorg (approximate spawn location) | Edron | -2 | 1 |
| Shooter spot | Roshamuul | -8 | 4 |
| Shops | Darashia | Surface | 3 |
| Shops and bank | Ankrahmun | 1 | 1 |
| Shulgrax | Southern Darama | -7 | 1 |
| Silver chimes | Tiquanda | -2 | 1 |
| Silver ewer (daily spawn) | Yalahar | 2, 1 | 3 |
| Silver nuggets (use pick) | Venore | -6 | 1 |
| Sir Leonard | Newhaven | -4 | 1 |
| Sir Leopold (exact spawn tile) | Newhaven | -3 | 1 |
| Sir Nictors and Baeloc, Darashia | Gray Beach | -6 | 1 |
| Sir Valorcrest (spawn location) | Edron | -3 | 1 |
| Sister Hetai | Issavi | -2 | 1 |
| Site GT-M-01 | Marapur | -8 | 1 |
| Skull Door | Isle of Destiny | -7 | 1 |
| Skull orchid | Krailos | Surface | 2 |
| Skulls on a Stonepile | Darashia | -4 | 1 |
| Sleeping hyaena | Krailos | Surface | 1 |
| Slide back to town | Rathleton | -5 | 1 |
| Slide to Glooth Factory | Rathleton | Surface | 1 |
| Slightly feline statue | Darashia | -5 | 1 |
| Slightly feline statue (cobra tongue) | Darashia | -1 | 1 |
| Slime training spot | Port Hope | Surface | 1 |
| Slug cave | Venore | Surface | 1 |
| Small lava pool (use to enter) | Ankrahmun | 4 | 1 |
| Small lava pool (use to exit) | Travora | -2 | 1 |
| Small pressure gauge | Rathleton | -5 | 1 |
| Smaller rose constellation | Marapur | 5 | 1 |
| Smaller Rose constellation | Marapur | 2 | 1 |
| Smuggler Baron Silvertoe (approximate spawn location) | Newhaven | -3 | 1 |
| Snake inscription | Darashia | -2 | 1 |
| Snake’s mouth (small topaz) | Darashia | -2 | 1 |
| Sneeze blossom | Roshamuul | Surface | 1 |
| Some eggs | Roshamuul | -5 | 8 |
| Sorcerer | Venore | -4 | 1 |
| Sorcerer and Druid spells | Darashia | Surface | 1 |
| Sorcerer spells | Ankrahmun | 1 | 1 |
| Sorcerer spells and magic training | Thais | Surface | 1 |
| Soup kettle | Newhaven | -6 | 1 |
| Source of Corruption room, including 2 upper floors | Venore | -8 | 1 |