| Dwarven pickaxe (daily spawn) | Kazordoon | -1, -2, -3, -4, -5, -6 | 11 |
| Dwarves | Feyrist | Surface | 2 |
| Dwelling of the Forgotten (a.k.a. Warzone 9) | Kazordoon | -3 | 1 |
| Dworcs | Port Hope | Surface | 1 |
| Earl Osam, Cormaya | Blue Valley | -6 | 1 |
| Earth elementals and bog raiders | Edron | Surface | 1 |
| Earth shrine (small emerald) | Feyrist | Surface | 1 |
| East teleport | Krailos | -6 | 1 |
| Eastern entrance to Venore | Venore | Surface | 1 |
| Eat colourful mushroom and enter | Isle of Destiny | -7 | 1 |
| Ebb and Flow (Goshnar’s Spite) | Blue Valley | -3 | 1 |
| Eclesius | Thais | Surface | 1 |
| Edron | Gnomegate | -2 | 1 |
| Edron Ruins (a.k.a. Hero Cave) | Edron | Surface | 1 |
| Egg cracker | Moonfall | -5 | 1 |
| Egg inscription | Darashia | -2 | 1 |
| Eldritch Dragon Lord | Venore | -5 | 1 |
| Elevator | Kazordoon | 5, -1, -2 | 3 |
| Elf overseer (spawn location) | Venore | -1 | 3 |
| Elite fanatics | Thalassara | 6 | 1 |
| Elven parchment | Oramond | -1 | 1 |
| Elvira Hammerthrust (spawn location) | Kazordoon | -4 | 1 |
| Elyrax's soul cage (use death and holy damage) | The Void | -8 | 1 |
| Emergency exit | Svargrond | -4, -5, -6 | 3 |
| Empty flask | Moonfall | -1, -2, -3, -4, -5 | 5 |
| Energy portal | Port Hope | -3 | 1 |
| Energy shrine (small amethyst) | Feyrist | 3 | 1 |
| Enter Necromant House | Venore | -1 | 1 |
| Entrance to digestion chamber | Gray Beach | Surface | 1 |
| Entrance to Goshnar’s Taint | Quirefang | -3 | 1 |
| Entrance to Kazordoon | Kazordoon | Surface | 1 |
| Entrance to Vortex Hub | Svargrond | -4 | 1 |
| Enusat the Onyx Wing | Issavi | Surface | 1 |
| Enusat the Onyx Wing (bomb spot) | Issavi | -1 | 1 |
| Epaminondas doll (Portal Tibia) | Thais | -2 | 1 |
| Eradicator (SD) | Svargrond | -7 | 1 |
| Eremo’s Island | Edron | Surface | 1 |
| Essence of Malice | Carlin | -3 | 1 |
| Essence of Malice room | Edron | -8 | 1 |
| Eustacio’s home | Venore | 1 | 1 |
| Evil Mastermind (exact spawn tile) | The Void | 6 | 1 |
| Evil sheep lord (fire bomb spot) | The Void | 2, 1, Surface | 3 |
| Evora (TibiaHome) | Thais | -3 | 1 |
| Evrard (night) | Newhaven | 1 | 1 |
| Ewer with holy water | Darashia | 1 | 1 |
| Excavation site Firefoot | Marapur | -8 | 1 |
| Excavation site Moss | Marapur | -8 | 1 |
| Exit | Newhaven | Surface, -1, -2, -3, -4, -5, -6, -7, -8 | 62 |
| Exultant ritual figurine | Venore | -2 | 1 |
| Fairy | Feyrist | -1, -2 | 4 |