| Scutty | Kazordoon | Dwarf | Technomancer | — |
| Sebastian | Liberty Bay | Human | Rebel | — |
| Second In Command Demeron | Roshamuul | Human | — | — |
| Secretive Rascoohan | Southern Darama | — | — | — |
| Ser Tybald | Dawnport | Human | Knight Guild Leader | — |
| Serafin | Yalahar | Human | Food Shopkeeper | sells |
| Servant Sentry | Edron | Machine | Servant | — |
| Sessek | Marapur | Lizard | Food Shopkeeper | sells |
| Seymour | Rookgaard | Human | Headmaster | — |
| Shadowpunch | Edron | Human | Supervisor | — |
| Shalmar | Darashia | Human | Druid Guild Leader | — |
| Shanar | Ab'Dendriel | Elf | Shopkeeper | buys and sells |
| Shanoya | Isle of Destiny | Human | Combat Instructor | — |
| Sharai | Marapur | — | — | — |
| Sharon | Thais | Human | Informer | — |
| Shauna | Carlin | Human | Officer | — |
| Sherry McRonald | Thais | Human | Farmer | buys and sells |
| Shiantis | Venore | Human | Equipment Shopkeeper | buys and sells |
| Shimun | Issavi | Human | Fisherman | — |
| Shiriel | Ab'Dendriel | Elf | Magic Shopkeeper | buys and sells |
| Shirith | Ab'Dendriel | Elf | Foreman | sells |
| Shirtalis of the Summer Court | Feyrist | Dreamelf | — | — |
| Shoddy Beggar | Edron | Human | Beggar | — |
| Sholley | Rathleton | Human | Representative | — |
| Shortsighted Dwarf | Kazordoon | Dwarf | Rebel | — |
| Siestaar | Roshamuul | Human | Inquisitor | — |
| Siflind | Svargrond | Human | Shaman | buys and sells |
| Sigurd | Kazordoon | Dwarf | Magic Shopkeeper | buys and sells |
| Silas | Rathleton | Human | Artisan | buys and sells |
| Simon the Beggar | Thais | Human | Beggar | sells |
| Sinatuki | Svargrond | Chakoya | Unknown Occupation | — |
| Sinclair | Edron | Human | Scientist | — |
| Sirik | Svargrond | Human | Guard | — |
| Sissek | Marapur | Lizard | Banker | — |
| Sister Of Jack | Edron | Human | Assistant | — |
| Skeleton Guard | Liberty Bay | Undead | Guard | — |
| Skip | Liberty Bay | Parrot | Guard | — |
| Skjaar | Thais | Human | Guard | sells |
| Skullfrost (NPC) | Edron | — | — | — |
| Smaralda | Thais | Human | Clairvoyant | sells |
| Smiley | Venore | Undead | Druid | — |
| Snake Eye | Venore | Human | Barkeeper | sells |
| Sniff | Venore | Corym | Merchant | — |
| Soilance | Yalahar | Human | Food Shopkeeper | sells |
| Solkrin (NPC) | Venore | Human | Gift Giver | — |
| Sorcerer Estrella | Isle of Destiny | Human | Sorcerer | — |
| Spectulus | Edron | Human | Scientist | — |
| Spirit Speaker | Venore | Human | Shaman | — |
| Sprout Sentinel | Oramond | Rootthing | Informer | — |
| Squeekquek | Liberty Bay | Corym | Merchant | — |